Phenytoin dosage adjustment

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Phenytoin dosage adjustment
Drug or Test. Interaction. Comments. Alcohol intake, acute. May increase serum phenytoin concentrations a. Monitor and adjust dosage accordingly. Alcohol intake, chronicDESCRIPTION. DILANTIN (phenytoin sodium) injection, USP is a sterile solution of 50 mg phenytoin sodium per milliliter for intravenous or intramuscular administration.Parenteral Phenytoing Sodium Injection is indicated for the treatment of generalized tonic-clonic status epilepticus, and prevention and treatment of seizures occurring during neurosurgery. intravenous phenytoin can also be substituted, as short-term use, for oral phenytoin.The phenytoin test is used to optimize drug therapy, monitor the amount of phenytoin in the blood, determine whether drug concentrations are in the therapeutic range, and to monitor patient adherence.3) Renal Failure (<10mL/min, dialysis) In patients with renal failure, uremia increases the unbound fraction of phenytoin. These patients also tend to have low serum albumin.For oral administration only. Dosage: Dosage should be individualised as there may be wide interpatient variability in phenytoin serum levels with equivalent dosage.Posology. Dosage: Dosage should be individualised as there may be wide interpatient variability in phenytoin serum levels with equivalent dosage.So wide is the variation in clearance rates that no dose which will produce effective levels of theophylline in most patients will fail to produce toxic levels in a few.Learn about Cipro (Ciprofloxacin) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.Acyclovir is the generic name for Zovirax, a prescription medication used to treat certain virus infections. The Food and Drug Administration (FDA) approved acyclovir to treat viral infections …Valproate has been administered to children as young as 2 years, but data on appropriate dosage based on age are limited. Younger children, especially those receiving concomitant enzyme-inducing anticonvulsants, may need larger maintenance doses to attain target total and unbound serum valproic acid concentrations compared to adults.Oxycodone is a narcotic medication used to relieve moderate to severe pain. OxyContin is a brand of timed-release oxycodone, made by Purdue Pharma, that works for up to 12 hours.500 mg PO twice daily, given with meals. If needed, increase the daily dosage by 500 mg at weekly intervals. Max: 2,000 mg/day PO, given in divided doses.So wide is the variation in clearance rates that no dose which will produce effective levels of theophylline in most patients will fail to produce toxic levels in a few.Learn about Cipro (Ciprofloxacin) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.Acyclovir is the generic name for Zovirax, a prescription medication used to treat certain virus infections. The Food and Drug Administration (FDA) approved acyclovir to treat viral infections …Valproate has been administered to children as young as 2 years, but data on appropriate dosage based on age are limited. Younger children, especially those receiving concomitant enzyme-inducing anticonvulsants, may need larger maintenance doses to attain target total and unbound serum valproic acid concentrations compared to adults.Oxycodone is a narcotic medication used to relieve moderate to severe pain. OxyContin is a brand of timed-release oxycodone, made by Purdue Pharma, that works for up to 12 hours.500 mg PO twice daily, given with meals. If needed, increase the daily dosage by 500 mg at weekly intervals. Max: 2,000 mg/day PO, given in divided doses.